UN Secretary General Ban Ki-moon condemned the anti-Islam film which was produced by extremist Jews and Copts in the United States, describing it as “hateful”.
But Ban also denounced the protests which took place against the US missions in several countries like Libya, Egypt and Yemen.
Ban is "deeply disturbed" by the eruption of deadly anti-US violence in Libya and other Middle East countries caused by the film which mocks Islam, a UN spokesperson Vannina Maestracci said.
"Nothing justifies such killings and attacks. He condemns the hateful film that appears to have been deliberately designed to sow bigotry and bloodshed," the spokesperson added.
"At this time of rising tensions, the secretary general calls for calm and restraint, and stresses the need for dialogue, mutual respect and understanding."
The film mocks the religion of Islam as it denigrates Prophet Mohammad (pbuh), sparking protest across some Islamic countries.
In Libya the US ambassador along with other three consulate officials were killed in the city of Benghazi.
Protests in Yemen also took place in which four people were killed as demonstrator tried to storm the US embassy there.
In the same context there were clashes between Egyptian protesters and police outside the US embassy in Cairo.